The pair have played each more than any other duo in the modern-day game, but after injury lay-offs and fitness doubts, the outcome of this afternoon’s last-four clash is anyone’s guess.
Follow all the live action below:
Anderson 7-6 (8-6) 6-7 (5-7) 2-1 Isner*
Isner batters a forehand return back past Anderson to kick this game off, but the South African is quickly back on form with another ace: that’s number 17.
He holds with a huge crosscourt forehand that Isner gamely charges for but is unable to return.
Anderson* 7-6 (8-6) 6-7 (5-7) 1-1 Isner
Isner whistles down his first ace of the third set: 15-all. But then a sniff of a break point for Anderson when Isner snatches at a forehand down the line, sending it long.
He levels it up with his trademark play: a big serve followed up by a forehand volley winner. And he holds with a truly sublime drop shot, possibly his best shot of the match. We’re on serve.
Anderson* 7-6 (8-6) 6-6 (3-6) Isner
Anderson hits back! His forehand has been purring but this time he goes with the backhand down the line, grabbing a mini-break and giving himself a glimmer of hope.
But Isner keeps his cool, whistling down a huge serve which Anderson can’t return. Three set points.
Anderson 7-6 (8-6) 6-6 Isner*
What a point! From the back of the court Anderson cranks up that forehand again but this time Isner gambles correctly; he springs to the net and slams the volley smash past his rival.
Anderson learns from his mistake though, winning the next two points with that very same shot hit from pretty much the same part of the court. One untidy backhand error from Isner and a big ace later and we’re set for our second tiebreak.
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Order of Play – Friday 13 July
1pm: (8) Kevin Anderson (Rsa) v (9) John Isner (USA), (12) Novak Djokovic (Ser) v (2) Rafael Nadal (Spa)
1pm: (12) Nicole Melichar (USA) & Kveta Peschke (Cze) v (6) Gabriela Dabrowski (Can) & Yi Fan Xu (Chn), Alicja Rosolska (Pol) & Abigail Spears (USA) v (3) Barbora Krejcikova (Cze) & Katerina Siniakova (Cze), Jay Clarke (Gbr) & Harriet Dart (Gbr) v Jamie Murray (Gbr) & Victoria Azarenka (Blr)
11.30am: Mansour Bahrami (Irn) & Goran Ivanisevic (Cro) v Jeremy Bates (Gbr) & Andrew Castle (Gbr), Conchita Martinez (Spa) & Barbara Schett (Aut) v Lindsay Davenport (USA) & Mary Joe Fernandez (USA), Jack Draper (Gbr) v (5) Nicolas Mejia (Col), (9) Michael Venus (Nzl) & Katarina Srebotnik (Slo) v (11) Alexander Peya (Aut) & Nicole Melichar (USA)
11.30am: (10) Xiyu Wang (Chn) v Leonie Kung (Swi), Iga Swiatek (Pol) v (4) Xin Yu Wang (Chn), (4) Maria Lourdes Carle (Arg) & Cori Gauff (USA) v Victoria Allen (Gbr) & Destinee Martins (Gbr), (1) Xin Yu Wang (Chn) & Xiyu Wang (Chn) v (5) Joanna Garland (Tpe) & En Shuo Liang (Tpe)
11.30am: Arnaud Clement (Fra) & Miles MacLagan (Gbr) v Greg Rusedski (Gbr) & Fabrice Santoro (Fra), (1) Chun Hsin Tseng (Tpe) v Tao Mu (Chn), Rinky Hijikata (Aus) & Naoki Tajima (Jpn) v Matheus Pucinelli De Almeida (Bra) & Joao Lucas Reis Da Silva (Bra), Clara Burel (Fra) & Diane Parry (Fra) v Dalayna Hewitt (USA) & Peyton Stearns (USA), Brandon Nakashima (USA) & Tyler Zink (USA) v (6) Nicolas Mejia (Col) & Ondrej Styler (Cze)
11.30am: Richard Krajicek (Ned) & Mark Petchey (Gbr) v Henri Leconte (Fra) & Cedric Pioline (Fra), Tracy Austin (USA) & Anne Keothavong (Gbr) v Kim Clijsters (Bel) & Rennae Stubbs (Aus), Yanki Erel (Tur) & Otto Virtanen (Fin) v (3) Hugo Gaston (Fra) & Clement Tabur (Fra), (7) Georgia Drummy (Irl) & Alexa Noel (USA) v (2) Catherine McNally (USA) & Whitney Osuigwe (USA), James Story (Gbr) & Harry Wendelken (Gbr) v (2) Aidan McHugh (Gbr) & Timofey Skatov (Kaz)